Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2), partial from MyBioSource.com

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Recombinant Human Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2), partial

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Description

This protein contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics